Our goal at Vaping.com is to 21+ nicotine consuming customers with the best possible alternatives to combustible cigarettes. This task has been made difficult by nicotine abstinence zealots intent on denying adult vapor consumers the flavors they prefer, even though the research is in and flavor bans increase cigarette sales. 

Depending on the city or state in which you live, it is likely you are aware of products like Spree Bar, Nixodine disposable vapes, NoNic6, Kumi, and other alternative products. Here is a guide to alternative products in 2025. 

All products listed below intended for adults (21+) and may be habit forming. Refer to each manufacturer’s warnings. Local regulations are subject to change. 

 
Nixodine by Bonguard Naturals

Nixodine™ is a patented formulation from Bonguard Naturals for adult smokers and nicotine vapers 21+. It’s engineered to provide a nicotine-like experience and is compatible with electronic vaping devices that use standard VG/PG e-liquid and flavors.

As a new product, Nixodine is undergoing extensive toxicity and long-term impact testing. According to Bonguard Naturals: “There is evidence to suggest Nixodine contains fewer hazardous chemicals than traditional nicotine vaping or combustible cigarettes.” While Vaping.com does not make any claims about Nixodine products, you can view additional testing and research at Bonguardnaturals.com. 

Nixodine Patents

• Nixodine Patents
  

Types of Nixodine

The most commercially popular version of Nixodine is Nixodine-S, which is for use in vaping devices.

• Nixodine-S is offered pre-diluted in propylene glycol (PG) or vegetable glycerin (VG) to work with today’s refillable hardware and disposable devices.
• Nixodine-S Salts is tailored for adult users 21+, delivering a feel comparable to disposable vapes, nicotine-salt e-liquids, and closed pod systems.
• Standard Nixodine-S is blended to provide an experience similar to traditional vape juices.
• Nixodine-S Polacrilex is a powdered, highly soluble form intended for formats such as pouches, lozenges, digestibles, and related products (per the manufacturer).
• Nixodine Pure is the active compound on its own—without VG/PG carriers or the polacrilex matrix.

What is it Like to Vape Nixodine?

Nixodine has less of a throat hit, allowing flavors to pop more clearly. With Nixodine-S salts crafted to mimic disposables and pod kits. Nixodine is formulated to provide a comparable vaping experience. Nixodine is intended for 21+ adult vapor consumers who already use nicotine.

Nixodine Disposable Vapes

Disposable devices remain the most popular format among adult nicotine vapers. Several established brands now offer Nixodine-based disposables. Through its patents and brand partnerships, Bonguard Naturals states it is pursuing the future of vaping in a transparent, accountable way.

 

Nixodine Products

• Fifty Bar 20K Nixodine - Up to ~20,000 puffs; ~18mL total capacity, USA assembled with e-liquid flavors from US master formulators.
• Hotbox Elite 50K - Up to ~50,000 puffs; ~30mL total capacity, three modes and airflow control.
• Lost Mary MT35K Nixodine - Up to ~35,000 puffs; ~22mL total capacity, authentic Lost Mary vaping experience.
• Katchmi Disposable - Up to ~20,000 puffs; ~16mL total capacity, dual modes and built-in USB-C cable.
• Mi-Pod NX Nixodine Pods - Draw-activated pod kit for gas station and convenience store customers.  
  • Mi-Pod NX Blade: Battery with form factor of Vuse Alto/Juul
  • Mi-Pod NX Pedal: Compact nano battery with 400mAh capacity. Compatible with Mi-Pod NX Nixodine pods.
  • Mi-Pod NX Pre-filled pods: 2ml Nixodine pods using Nixodine 50. Mesh coil, anti-leak coil.
• Nix Liquids: 100ml Nix Liquids bottles come in 6, 12 and 18 strength Nixodine and 30ml Nix Salts bottles come in 18, 36, and 50 strength Nixodine.

 
Metatine

Metatine is a synthetic, non-nicotine compound that shares a similar structure with certain vaping alkaloids while remaining chemically distinct according to their website. The company markets devices using Metatine as delivering adult users a level of satisfaction comparable to conventional nicotine vape products.
On regulation, the manufacturer states that because Metatine contains no nicotine, is not sourced from tobacco, and isn’t a tobacco component, it believes the product falls outside the FDA Center for Tobacco Products’ oversight.

Metatine Products

• SPREE BAR device (rechargeable) — Type-C charging, ~600 mAh battery; offered as a starter kit paired with prefilled pods.
• SPREE BAR prefilled flavor pods — ~12 mL per pod, up to ~6,000 puffs.
• Juice Head iFlex Disposable Vape - 18ml disposable vape with flavor control, expected to be launched in Q4 2025. 

NoNic6

On the Kumi website, NoNic6™ is described as a non-nicotine compound used as a substitute for nicotine—close in structure but chemically distinct from other vaping alkaloids, not derived from nicotine or tobacco—and is the active ingredient in Kumi 6 devices for adult users. 

NoNic6 Products

• Kumi 6: Up to ~10,000 puffs; ~16 mL e-liquid; rechargeable; battery indicator.
• Kumi 6 Kurve: Up to ~35,000 puffs; ~28 mL e-liquid; dual-mesh; ~900 mAh.
• Kumi 6 Scenic: Up to ~50,000 puffs; ~22 mL total capacity (visible tank + prefill); digital screen.
  

Our Verdict

Nixodine has a robust rselection of products made by trusted brands like like Fifty Bar, Lost Mary, and Keep It 100. They are transparent, have an array of patents, and have spent considerable time and money obtaining toxicity data. They were not the first product to market but they have allied with companies that market responsibly. This is crucial if Nixodine is to emerge as a viable alternative for adult vapor consumers.